Authors
Loskutov I. À.
Doctor of Medicine, Head of Department1
Ekgardt V. F.
Doctor of Medicine, Professor, Chair of Eye Diseases2
Dorofeev D. A.
M.D.3
Petrov S. Yu.
Ph.D, Leading Research Associate of the Glaucoma Department4
Volzhanin A. V.
resident4
1 - Ophthalmology Department, Research Clinical Center of JSC «Russian Railways», 20 Chasovaya str., Moscow, Russian Federation, 125315
2 - The South Ural State Medical University of Russian Federation Ministry of Healthcare
3 - Public Clinical Hospital of Chelyabinsk #3, 287 Pobedy Ave., Chelyabinsk, Russian Federation, 454021
4 - Scientific Research Institute of Eye Diseases, 11a Rossolimo st., Moscow, Russian Federation, 119435
Corresponding author
Dorofeev D.A. E-mail: dimmm.83@mail.ru
Conflict of Interest and Source Funding
None declared.
Abbreviated title
Clinical efficacy of lutein-containing drugs in the treatment of combined POAG and nonexudative ARMD.
Abstract
Purpose: To evaluate a visual acuity dynamics in patients with combined primary open-angle glaucoma (POAG) and non-exudative age-related macular degeneration (ARMD) with a long-term continuous use of lutein-containing drugs.
To evaluate informativeness of visual acuity estimation methods (charts of Sivtsev-Golovin and EDTRS).
Methods: 32 patients (64 eyes) with combined pathology of POAG (initial and advanced stages) and ARMD (AREDS I-II) were divided equally into two groups. The study group received lutein-containing drug Superoptic (Akrikhin, Poland), 1 capsule per day with the meals during 1 year. The control group didn’t receive any lutein-containing drugs during all the study period.
Data received was processed in R Core Team.
Results. By the moment of study beginning in the control group visual acuity (VA) and best corrected visual acuity (BCVA) defined by Sivtsev-Golovin charts was 0,44±0,29 and 0,65±0.26, respectively. In 3 months VA and BCVA have improved and were 0,47±0,30 and 0,68±0,25. In 6 months VA and BCVA were 0,48±0,30 and 0,68±0.26. In a year VA and BCVA were 0,47±0,31 and 0,68±0.26.
Defined by EDTRS, VA and BCVA by the beginning of the study were 31,44±16,40 and 43,84±11,79 respectively. In 3 months VA and BCVA have improved and were 35,69±15,64 and 46,84±11,69. In 6 months VA and BCVA were 37,62±14,35 and 46,81±10,28. In a year VA and BCVA were 38,38±14,74 and 48,69±10,12.
In the control group VA and BCVA, determined by Sivtsev-Golovin chart, by the moment of study beginning were 0,45±0,31 and 0,71±0.21 respectively. During the study, there were insignificant changes in VA and BCVA. In 3 months they were 0,46±0,30 and 0,71±0.20, in 6 months 0,46±0,31 and 0,71±0.20, and in 12 months 0,42±0,27 and 0,71±0.19, respectively.
Defined by EDTRS, VA and BCVA in the control group were 27,78±16,79 and 41,25±9,16; in 3 months they were 27,81±16,68 and 41,09±9,22, in 6 months they were 27,91±16,68 and 1,00±9,04, and in 12 months VA and BCVA were 27,31±16,21 è 40,94±9,04.
Conclusion: Long-term continuous use of lutein-containing drugs in patients with combined pathology of POAG and ARMD leads to the visual acuity improvement.
Using of modified ETRDS charts with Russian optotypes allows to perform a visual acuity examination more precisely.
Key words
glaucoma, age-related macular degeneration, lutein-containing drugs, EDTRS
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