Authors
Martusevich A. K.
Doctor of Biology, Head, University clinics Medical Byophysics laboratory1
Dmitrochenkov A. V.
Doctor of Medicine, Head, Chair for Medical Rehabilitation1
Razumovsky A. V.
Doctor of Medicine, Professor, Chair for Medical Rehabilitation1
Galova E. A.
PhD, Scientific Director, University clinics1
1 - Volga Research Medical University, Nizhny Novgorod
Corresponding author
Andrey K. Martusevich e-mail: cryst-mart@yandex.ru
Conflict of interest
None declared.
Abstract
The article systemizes data on a new medical science field – biocrystallomics in experimental and clinical combustiology. Research in the area is based on the complex study of human and animals’ crystallogenic and initiated properties of any biological substrata by special methodology and methods system. Potential spheres of biocrystallomics methods use in clinical combustiology are shown. There are burn disease complications diagnostics, pharmacotherapy choice and its effectiveness monitoring, burn results prognosing etc. Possibilities of biocrystallomics methods use as metabolic status estimation instrument at burn experimental modeling are demonstrated.
Key words
biocrystallomics, combustiology, metabolism, diagnostics, biocrystallization
DOI
References
1. Antropova I.P., Gabinskij Ya.L. Kristallizaciya biozhidkosti v zakrytoj yachejke na primere slyuny [Crystallization of a biofluid in a closed cell by the example of saliva]. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnostics] 1997; (8): 36-38. (In Russ.)
2. Bajdaulet I.O. Kristallograficheskie svojstva spinnomozgovoj zhidkosti pri hronicheskoj intoksikacii neorganicheskimi soedineniyami fosfora [Crystallographic properties of cerebrospinal fluid in chronic intoxication with inorganic phosphorus compounds]. Zhurnal nevrologii i psihiatrii im. S. S. Korsakova [S. S. Korsakov Journal of Neurology and Psychiatry] 2003; (6): 50-52.
3. Barer G.M., Denisov A.B., Sturova T.M. Variabel'nost' kristallicheskih agregatov rotovoj zhidkosti v norme [Normal variability of crystalline aggregates of the oral liquid]. Rossijskij stomatologicheskij zhurnal [Russian Dental Journal] 2003; (1): 33-35.
4. Barer G.M., Denisov A.B., Mihaleva I.N. et al. Kristallizaciya rotovoj zhidkosti. Sostav i chistota poverhnosti podlozhki [Crystallization of oral fluid. Composition and cleanliness of the substrate surface]. Byulleten' ehksperimental'noj biologii i mediciny [Bulletin of Experimental Biology and Medicine] 1998; 126 (12): 693-696.
5. Barinov E.F., Karasev I.V. Lokalizaciya povrezhdeniya v kanal'cah nefrona pri termicheskoj travme kozhi [Localization of damage in the tubules of the nephron during thermal skin trauma]. Arhiv klinicheskoj i ehksperimental'noj mediciny [Archive of Clinical and Experimental Medicine] 2004; 13 (1-2): 18-21.
6. Barinov E.F., Lam M.M. Rol' metabolitov arahidonovoj kisloty v narushenii osmoticheskogo koncentrirovaniya u krys posle termicheskoj travmy kozhi [The role of arachidonic acid metabolites in the disturbance of osmotic concentration in rats after thermal skin injury]. Tavricheskij mediko-biologicheskij vestnik [Tavrichesky medico-biological bulletin] 2006; 9 (1): 122-126.
7. Bolgov S.V., Loshkarev V.P., Korotkih N.G. et al. Vliyanie faktorov vneshnej sredy na kristallizaciyu rotovoj zhidkosti [The influence of environmental factors on the crystallization of the oral fluid]. Stomatologiya [Stomatology] 2002; 81 (4): 13-16.
8. Vorob'ev A.V., Martusevich A.K., Peretyagin S.P. Kristallogenez biologicheskih zhidkostej i substratov v ocenke sostoyaniya organizma [Crystallogenesis of biological fluids and substrates in assessing the state of the body.]. Nizhnij Novgorod: FGU «NNIITO Rosmedtekhnologij»; 2008.
9. Vorob'ev A.V., Peretyagin S.P., Pogodin I.E. et al. Novaya tekhnologiya v ocenke tyazhesti ehndotoksemii pri ozhogovoj bolezni [New technology in assessing the severity of endotoxemia in burn disease]. Nizhegorodskij medicinskij zhurnal, Pril. «Travmatologiya, ortopediya, kombustiologiya» [Nizhny Novgorod Medical Journal, Suppl. Traumatology, Orthopedics, Combustiology] 2006: 296-298.
10. Gromova I.P. Kristalloskopicheskij sposob izucheniya syvorotki krovi v toksikologo-gigienicheskom ehksperimente metodom «otkrytaya kaplya» [Crystalloscopic method of studying blood serum in a toxicological-hygienic experiment by the «open drop» method]. Gigiena i sanitariya [Hygiene and sanitation] 2005; (2): 66-69.
11. Devyatkin A.A., Shatohina S.N., Shabalin V.N. et al. Morfologicheskaya kartina vodyanistoj vlagi v ocenke patofiziologicheskih mekhanizmov involyutivnogo kataraktogeneza [Morphological picture of watery moisture in the evaluation of pathophysiological mechanisms of involutive cataractogenesis]. Vestnik oftal'mologii [Bulletin of Ophthalmology] 2004; (1): 40-42.
12. Denisov A.B. Algoritm ocenki kristallicheskih figur, poluchennyh pri vysushivanii smeshannoj slyuny [Algorithm for evaluating crystalline figures obtained by drying mixed saliva]. Byulleten' ehksperimental'noj biologii i mediciny [Bulletin of Experimental Biology and Medicine] 2004; 136 (7): 37-40.
13. Denisov A.B. Mikrokristallizaciya slyuny: novye metodicheskie podhody [Microcrystallization of saliva: new methodological approaches.]. Stomatologiya [Stomatology] 2007; 86 (5): 20-23
14. Deryabina N.I., Zaleskij M.G. Soderzhanie belkovyh komponentov v kaple syvorotki krovi pri ee vysyhanii [The content of protein components in a drop of blood serum when it dries]. Vestnik novyh medicinskih tekhnologij [Bulletin of new medical technologies] 2005; 12 (1): 85-87.
15. Zaleskij M.G., EHmanuehl' V.L. Fiziko-himicheskaya interpretaciya rezul'tatov issledovaniya litogennoj mochi s pomoshch'yu diagnostikuma «Litos-sistema» [Physicochemical interpretation of the results of the study of lithogenic urine with the help of the Diagnosticum «Lithos-system»]. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnostics] 2005; (12): 19-23.
16. Kamakin N.F., Martusevich A.K., Koshkin A.N. Perspektivy razvitiya kristallograficheskih metodov issledovaniya [Prospects for the development of crystallographic methods of research]. Vyatskij medicinskij vestnik [Vyatka medical bulletin] 2003; (3): 6-11.
17. Kidalov V.N., Hadarcev A.A., Yakushina G.N. Teziograficheskie issledovaniya krovi i ih prakticheskie vozmozhnosti [Thersiographic studies of blood and their practical possibilities]. Vestnik novyh medicinskih tekhnologij [Bulletin of new medical technologies] 2004; 11 (1-2): 23-25.
18. Kuznecov N.N., Vershinina G.A., Skopinov S.M. Optiko-polyarizacionnye i refraktometricheskie metody v ocenke stepeni tyazhesti sindroma ehndogennoj intoksikacii u detej. Sb. nauch. tr. 2-j vseross. nauchno-prakt. konf. «Morfologiya biologicheskih zhidkostej v diagnostike i kontrole ehffektivnosti lecheniya» [Optical-polarization and refractometric methods in assessing the severity of the syndrome of endogenous intoxication in children. Collected works of the 2-nd All-Russian scientific and practical conference «Morphology of biological fluids in the diagnosis and control of the effectiveness of treatment»]. Moscow, 2001: 30-33.
19. Kulmagambetov I.R., Muravleva L.E., Kojkov V.V. Sostoyanie okislitel'nogo metabolizma i kristalloobrazuyushchie svojstva krovi ehksperimental'nyh zhivotnyh pri intoksikacii nesimmetrichnym dimetilgidrazinom [The state of oxidative metabolism and crystal-forming properties of blood of experimental animals with intoxication with asymmetric dimethylhydrazine]. Biomedicinskaya himiya [Biomedical Chemistry] 2007; 53 (3): 276-283.
20. Kurnysheva N.I., Nagornova N.D., Deev A.I. Issledovanie sleznoj zhidkosti v prognozirovanii techeniya glaukomatoznoj opticheskoj nejropatii [Investigation of tear fluid in predicting the course of glaucomatous optic neuropathy]. Klinicheskaya gerontologiya [Clinical gerontology] 2003; (9): 91.
21. Martusevich A.K. Biokristallomika kak nauka o spontannom, napravlennom i upravlyaemom biokristallogeneze [Biocrystallomics as a science of spontaneous, directed and controlled biocrystallogenesis]. Informatika i sistemy upravleniya [Informatics and management systems] 2008; (2): 145-148.
22. Martusevich A.K., Peretyagin S.P. Rol' kristallografii biosred pri ocenke ehffektivnosti lecheniya ozhogovogo ehndotoksikoza [The role of crystallography of bio-agents in assessing the effectiveness of treatment of burn endotoxicosis]. Medicinskaya pomoshch'[Medical care] 2008; (2): 11-14.
23. Martusevich A.K., Peretyagin S.P., Pogodin I.E. et al. Teziokristalloskopicheskij «portret» pacienta s ozhogovoj bolezn'yu v zavisimosti ot stepeni ehndotoksikoza [Tesiocrystalloscopic «portrait» of a patient with a burn disease, depending on the degree of endotoxicosis]. Kazanskij medicinskij zhurnal [Kazan Medical Journal] 2007; 88 (4) Suppl.: 311-312.
24. Martusevich A.K., Kamakin N.F. Unificirovannyj algoritm issledovaniya svobodnogo i iniciirovannogo kristallogeneza biologicheskih zhidkostej [Unified algorithm for studying free and initiated crystallogenesis of biological fluids]. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnostics] 2007; (6): 21-24.
25. Mihaleva I.N., Revokatova I.P., Barer G.M. et al. Kristallizaciya rotovoj zhidkosti pri razlichnyh usloviyah [Crystallization of the oral fluid under various conditions]. Problemy nejrostomatologii i stomatologii [Problems of Neurostomatology and Dentistry] 1998; (1): 4-6.
26. Paramonov B.A., Porembskij Y.O., Yablonskij V.G. Ozhogi: rukovodstvo dlya vrachej [Burns: a guide for doctors]. SPb.: SpecLit; 2000.
27. Peretyagin S.P., Martusevich A.K., Pogodin I.E. Laboratornyj kontrol' ehffektivnosti ozonoterapii ozhogovogo ehndotoksikoza [Laboratory monitoring of the effectiveness of ozonotherapy for burn endotoxicosis]. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnostics] 2007; (9): 64.
28. Plaksina G.V., Rimarchuk G.V., Butenko S.V. Klinicheskoe znachenie kristallograficheskogo i kristalloskopicheskogo metoda issledovaniya mochi [Clinical significance of crystallographic and crystalloscopic method of urinalysis]. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnostics] 1999; (10): 34.
29. Rapis E.G. Belok i zhizn'. Samoorganizaciya, samosborka i simmetriya nanostrukturnyh supramolekulyarnyh plenok belka [Protein and life. Self-organization, self-assembly and symmetry of nanostructured supramolecular protein films]. Moscow: «MILTA – PKP GIT», 2003.
30. Savina L.V. Kristalloskopicheskie struktury syvorotki krovi zdorovogo i bol'nogo cheloveka [Crystalloscopic structures of blood serum in healthy and sick people]. Krasnodar, 1999.
31. Savina L.V., Kokueva O.V., Yakovenko M.S. Metabolicheskie struktury syvorotki krovi pri ehndogennoj intoksikacii u bol'nyh hronicheskim pankreatitom [Metabolic structures of blood serum in endogenous intoxication in patients with chronic pancreatitis]. Eksperimental'naya i klinicheskaya gastroehnterologiya [Experimental and clinical gastroenterology] 2007; Suppl. 1: 265.
32. Savina L.V., Pavlishchuk S.A., Samsygin V.Y. et al. Polyarizacionnaya mikroskopiya v diagnostike obmennyh narushenij [Polarization microscopy in the diagnosis of metabolic disorders]. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnostics] 2003: (3): 11-13.
33. Savina L.V. Strukturoobrazovanie syvorotki krovi v usloviyah vakuuma [Structurization of blood serum under vacuum]. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnostics] 1999; (11): 48.
34. Tarasevich Yu.Yu. Mekhanizmy i modeli degidratacionnoj samoorganizacii biologicheskih zhidkostej [Mechanisms and models of dehydration self-organization of biological fluids]. Uspekhi fizicheskih nauk [Successes of physical sciences] 2004; 174 (7): 779-790.
35. Tarusinov G.A. Kristallograficheskoe issledovanie mochi v diagnostike i differencial'noj diagnostike diffuznyh zabolevanij soedinitel'noj tkani u detej [Crystallographic examination of urine in the diagnosis and differential diagnosis of diffuse connective tissue diseases in children]. Pediatriya [Pediatrics] 1994; (1): 55-57.
36. Trizno N.N., Bednov I.A., Rezaev A.A. Morfologicheskie osobennosti biozhidkostej organizma krys pri hronicheskom vozdejstvii serosoderzhashchego gaza [Morphological features of biofluids in the body of rats during chronic exposure to sulfur-containing gas]. Vestnik novyh medicinskih tekhnologij [Bulletin of new medical technologies] 2003; (1-2): 23-24.
37. Shabalin V.N., Shatohina S.N. Morfologiya biologicheskih zhidkostej v klinicheskoj laboratornoj diagnostike [Morphology of biological fluids in clinical laboratory diagnostics]. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnostics] 2002; (3): 25-32.
38. Shabalin V.N., Shatohina S.N. Morfologiya biologicheskih zhidkostej cheloveka [Morphology of human biological fluids]. Moscow: Hrizopraz, 2001.
39. Shatohina S.N. Znachenie biomineralizacii v norme i patologii [The importance of biomineralization in norm and pathology]. Medicinskaya kafedra [Medical Chair] 2006; (1): 14-19.
40. Sheverdin Yu.P., Chumak P.Ya. Kristallograficheskoe issledovanie krovi u bol'nyh ostrym pankreatitom [Crystallographic study of blood in patients with acute pancreatitis]. Klinicheskaya hirurgiya [Clinical Surgery] 1987; (11): 64-65.
41. Yushchenko A.A., Daudova A.D., Ayupova A.K. et al. Ispol'zovanie morfostrukturnoj reakcii syvorotki krovi v toksikologicheskoj ocenke lekarstvennyh sredstv [The use of the morphostructural reaction of blood serum in the toxicological evaluation of drugs]. Byulleten' ehksperimental'noj biologii i mediciny [Bulletin of Experimental Biology and Medicine] 2004; 140 (7): 113-117.
42. Azoury R., Garside J., Robertson W.G. Calcium oxalate precipitation in a flow system: An attempt to stimulate in the early stages of stone formation in the renal tubules. J. Urol. 1986; 136 (1): 150-153.
43. Chernov A.A. Crystall growth and crystallography. Acta Crystallography 1998; 54 (1): 859-872.
44. Kitamura M., Ueno S., Sato K. Molecular aspects of the polymorphic crystallization of amino acids and lipids. In: Othaki H., editors. Crystallization processes. Chichester: John Wiley and Sons, 1998, Vol. 3, Š. 99.
45. Maksimov S.A., Kureljak D.S. Some characteristics of separateness of facia of the whey of blood. Bull. Int. Sci. Surg. Ass. 2006; 1 (3): 63-64.
46. Martusevich A.K., Kamakin N.F. Crystallography of biological fluid as a method of evaluating its physicochemical characteristics. Bull. Exper. Biol. Med. 2007; 143 (3): 385-358.
47. Pauchard, L., Parisse F., Allain C. Influence of salt content on crack patterns formed through colloidal suspension desiccation. Phys. Rev. E. 1999; 59: 3737.
48. Ryall R.L., Hibberd C.M., Mazzachi B.C. Inhibitory activity of whole urine: a comparison of urines from stone formers and healthy subjects. Clin. Chim. Acta 1986; 154 (1): 59-67.
49. Sener G., Kabasakal L., Cetinel S. Leukotriene receptor blocker montelukast protects against burn-induced oxidative injury of the skin and remote organs. Burns 2005; 31 (5): 587-596.
50. Shabalin V.N., Shatokhina S.N., Yakovlev S.A. Character of blood crystallization as an integral index of organism homeostasis. Phys. Chem. Biol. Med. 1995; 2 (1): 6-9.
51. Singe, A.J., Berruti L., Thode H.C.Jr. et al. Standardized burn model using a multiparametric histologic analysis of burn depth. Acad. Emerg. Med., 2000; 7 (1): 1-6.
52. Yakhno T., Yakhno V., Sanin A. et al. Dynamics of Phase Transitions in Drying Drops as an Information Parameter of Liquid Structure. Nonlinear Dynamics 2002; 39 (4): 369-374.