AboutContactsEditorial StaffEditorial CouncilArchiveFor AuthorsFor Reviewers

Comparative review of the principles and methods of drug treatment applied in Europe and in the Russian Federation

Journal «MEDICINA» ¹ 3, 2018, pp.19-37 (Reviews)

Authors

Bryun E. A.
Doctor of Medicine, Professor, President1

Koshkina E. A.
Doctor of Medicine, Professor, Head, Department of Scientific and Clinical Research1

Vinnikova M. A.
Doctor of Medicine, Professor1

Sokolchik E. I.
PhD, Head, Department of Medical Aid Quality Expertise1

Valkova U. V.
PhD, Senior Researcher1

Smirnovskaya M. S.
Researcher1

1 - Moscow Research and Practical Center on Addictions of Moscow Department of Healthcare, Moscow, Russian Federation

Corresponding Author

Koshkina Evgeniya, e-mail: epid@list.ru

Conflict of Interest

None declared.

Funding

The study had no sponsorship.

Abstract

A comparative analysis of the principles and methods of treatment of drug addiction used in Europe and in the Russian Federation, based on the study of foreign and domestic scholarly publications is presented. Approaches to drug treatment are based on following general principles: examination, evaluation, diagnosis and treatment planning. This activity is conducted according to Treatment Standards and Clinical Recommendations developed by leading specialists of the respective countries, taking into account the evidence level of the effectiveness of treatment methods and ethical norms. Unlike the world practice, in Russia there is a state addiction service that provides free territorial-based treatment to addicted patients. The implementation of methods and ways of treatment in Russia coincides with the international standards of respective methods and ways of treatment of drug use disorders, recommended by UNODC and WHO. Those include awareness raising in the population at different levels: surveys, short-term interventions and referral to inpatient care, outpatient and rehabilitation. The main differences in European and Russian approaches are in the field of the intervention measures aimed at reducing the negative consequences of drug use, the so-called harm reduction measures, including substitution maintenance therapy.

Key words

principles, methods, treatment, drug addiction, prevalence

DOI

References

1. Voronin K.E., Rohlina M.L., Petrakova L.B. Klinicheskie proyavleniya i patogeneticheskie metody lecheniya opijnogo abstinentnogo sindroma. Aktualnye problemy mediko-social'noj reabilitacii bol'nyh alkogolizmom i narkomaniyami. Sbornik nauchnych trudov [Clinical manifestations and pathogenetic methods of treatment of opium withdrawal syndrome. Urgent problems of medical and social rehabilitation of alcoholics and drug addicts. Collected scientific works]. Moscow, 1994: 125-129. (In Russ.)

2. Gosudarstvennaya medicinskaya statistika Minzdrava Rossii 2016-2017 g.g. Forma ¹11, «Svedeniya o zabolevaniyah narkologicheskimi rasstrojstvami»; Forma ¹37 «Svedeniya o pacientah, bol'nyh alkogolizmom, narkomaniyami, toksikomaniyami», utverzhdeny Prikazom Rosstata ot 16.10.2013g. ¹410 [State medical statistics of the Ministry of Health of Russia 2016-2017. Form No. 11, «Information on diseases of narcological disorders»; Form No. 37 «Information on patients with alcoholism, drug addiction, substance abuse», approved by the Order of Rosstat of 16.10.2013. ¹410]. (In Russ.)

3. Doklad Mezhdunarodnogo komiteta po kontrolyu nad narkotikami za 2017 god. Izdanie organizacii obedinennyh nacij Vena, 2018 g., [INCB report-2017. World Health Organization, Wien, 2018] elSBN: 978-92-1-363144-7 ISSN 0257-3768. (In Russ.)

4. Ivanec N.N., Anohina I.P., Vinnikova M.A. Novaya prolongirovannaya forma naltreksona – «prodetokson, tabletki dlya implantacii» v kompleksnoj terapii bol'nyh s zavisimost'yu ot opiatov [The new prolonged form of naltrexone – «Protektoxone, tablets for implantation» in the complex therapy of patients with opiate dependence]. Voprosy narkologii [Issues of narcology] 2005; (3): 3-13. (In Russ.)

5. Ivanec N.N., Vinnikova M.A. Opyt primeneniya vivitrola (naltrekson dlitel'nogo dejstviya) v zarubezhnoj praktike [Experience with vivitrol (long-acting naltrexone) in foreign practice]. Voprosy narkologii [Issues of narcology] 2008; (6): 73-85. (In Russ.)

6. Ivanec N.N., Vinnikova M.A. Opyt primeneniya ksefokama (lornoksikama) pri kupirovanii bolevogo sindroma u bol'nyh geroinovoj narkomaniej [Experience with the use of xefokam (lornoxicam) in the management of pain syndrome in patients with heroin addiction]. Voprosy narkologii [Issues of narcology] 2001; (4): 3-9. (In Russ.)

7. Krupickij E.M., Blohina E.A. Primenenie prolongirovannyh form naltreksona dlya lecheniya zavisimosti ot opiatov [The use of prolonged forms of naltrexone in the treatment of opiate dependence]. Voprosy narkologii [Issues of narcology] 2010; (4): 32-43. (In Russ.)

8. Krupickij E.M., Zvartau E.E., Blohina E.A., Woody G. Primenenie razlichnyh lekarstvennyh form naltreksona dlya lecheniya zavisimosti ot opioidov [Application of various naltrexone dosage forms in the treatment of opioid dependence]. Zhurnal nevrologii i psihiatrii im. S.S .Korsakova [S.S. Korsakov Journal of Neurology and Psychiatry] 2011; (11-2): 66-72. (In Russ.)

9. Krupickij E.M., Zvartau E.E., Coj M.V., Masalov D.V., Burakov A.M., Egorova V.Yu., Didenko T.Yu., Romanova T.N., Ivanova E.B., Bespalov A.Yu., Verbickaya E.V., Neznanov N.G., Grinenko A.Ya., O'Brien C.P., Woody G. Dvojnoe slepoe randomizirovannoe placebokontroliruemoe issledovanie effektivnosti naltreksona dlya stabilizacii remissij u bol'nyh geroinovoj narkomaniej [A double-blind, randomized placebo-controlled study of naltrexone for stabilizing remissions in patients with heroin addiction]. Uchenye zapiski SPbGMU im. akad. I. P. Pavlova [The Scientific Notes of the I. P. Pavlov St. Petersburg State Medical University] 2003; 10 (2): 23-30. (In Russ.)

10. Krupickij E.M., Zvartau E.E., Coj M.V., Masalov D.V., Burakov A.M., Egorova V.Yu., Didenko T.Yu., Romanova T.N., Ivanova E.B., Bespalov A.Yu., Verbickaya E.V., Neznanov N.G., Grinenko A.Ya., O'Brien C.P., Woody G. Dvojnoe slepoe randomizirovannoe placebo-kontroliruemoe issledovanie effektivnosti naltreksona dlya stabilizacii remissij u bol'nyh geroinovoj narkomaniej [A double-blind, randomized, placebo-controlled trial of naltrexone for stabilizing remissions in patients with heroin addiction]. Voprosy narkologii [Issues of narcology] 2005; (3): 24-35. (In Russ.)

11. Krupickij E.M., Ilyuk R.D., Mihajlov A.D., Kazankov K.A., Rybakova K.V., Skurat E.P., Grishina O.G., Zaplatkin I.A., Vetrova M.V., Neznanov N.G. Randomizirovannoe kontroliruemoe issledovanie effektivnosti pregabalina v terapii sindroma otmeny opiatov [A randomized controlled trial of the efficacy of pregabalin in the treatment of opiate withdrawal syndrome]. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova [S.S. Korsakov Journal of Neurology and Psychiatry] 2016; (7): 29-36. (In Russ.)

12. Krupickij E.M., Nunes E.V., Ling U., Illeperuma A., Gastfriend A.R., Blohina E.A., Silverman B.L. Inekcionnaya forma naltreksona prolongirovannogo dejstviya dlya lecheniya opioidnoj zavisimosti: dvojnoe slepoe randomizirovannoe placebo-kontroliruemoe mnogocentrovoe issledovanie [Injectable form of sustained-release naltrexone for the treatment of opioid dependence: a double-blind, randomized, placebo-controlled, multicentre study]. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova [S.S. Korsakov Journal of Neurology and Psychiatry] 2012; (5): 3-11. (In Russ.)

13. Narkologiya: nacional'noe rukovodstvo. Pod red. N.N. Ivanca, I.P. Anohinoj, M.A. Vinnikovoj, 2-e izdanie, pererabotannoe i dopolnennoe [Narcology: national guidelines. Edited by N.N. Ivanets, I.P. Anokhina, M.A. Vinnikova. 2-nd edition, revised and enlarged]. Ìoscow: GEOTHAR-Media, 2016. (In Russ.)

14. Prikaz Ministerstva zdravoohraneniya Rossijskoi Federacii ot 30 dekabrya 2015 g. N 1034n «Ob utverzhdenii Poryadka okazaniya medicinskoj pomoshchi po profilyu »psihiatriya-narkologiya« i Poryadka dispansernogo nablyudeniya za licami s psihicheskimi rasstrojstvami i (ili) rasstrojstvami povedeniya, svyazannymi s upotrebleniem psihoaktivnyh veshchestv» [Order of the Ministry of Health of the Russian Federation of December 30, 2015 N 1034n «On approval of the order of rendering medical assistance on the profile of »psychiatry-narcology« and the Order of dispensary observation of persons with mental disorders and (or) behavioral disorders associated with the use of psychoactive substances»]. (In Russ.)

15. Prikaz Ministerstva obrazovaniya i nauki Rossijkoj Federacii ot 25 avgusta 2014 g. N 1063 «Ob utverzhdenii federal'nogo gosudarstvennogo obrazovatel'nogo standarta vysshego obrazovaniya po special'nosti 31.08.21 Psihiatriya-narkologiya (uroven' podgotovki kadrov vysshej kvalifikacii)» [Order of the Ministry of Education and Science of the Russian Federation of August 25, 2014 N 1063 «On approval of the federal state educational standard of higher education in specialty 31.08.21 Psychiatry-Narcology (level of training of highly qualified personnel)»]. (In Russ.)

16. Prikaz Ministerstva zdravoohraneniya Rossijskoj Federacii ot 11.11.2013 N 837 (red. ot 09.06.2015) «Ob utverzhdenii Polozheniya o modeli otrabotki osnovnyh principov nepreryvnogo medicinskogo obrazovaniya specialistov s vysshim medicinskim obrazovaniem v organizaciyah, osushchestvlyayushchih obrazovatel'nuyu deyatel'nost', nahodyashchihsya v vedenii Ministerstva zdravoohraneniya Rossijskoj Federacii, s uchastiem medicinskih professional'nyh nekommercheskih organizacij» [Order of the Ministry of Health of the Russian Federation of 11.11.2013 N 837 (Edited on 09.06.2015) «On approval of the Regulation on the model of working out the basic principles of continuous medical education of specialists with higher medical education in organizations engaged in educational activities under the Ministry of Health of the Russian Federation, with the participation of medical professional non-profit organizations»]. (In Russ.)

17. Prikaz Ministerstva zdravoohraneniya RF ot 17 maya 2016 g. ¹ 299n «Ob utverzhdenii standarta pervichnoj specializirovannoj mediko-sanitarnoj pomoshchi pri sindrome zavisimosti, vyzvannom upotrebleniem psihoaktivnyh veshchestv» [Order of the Ministry of Health of the Russian Federation of May 17, 2016 No. 299n «On the approval of the standard of primary specialized health care in the dependence syndrome caused by the use of psychoactive substances.»] (In Russ.)

18. Psihiatriya: nacional'noe rukovodstvo [Psychiatry: National Guidelines]. Pod red. Yu.A. Aleksandrovskogo, N.G. Neznanova. 2-e izdanie, pererabotannoe i dopolnennoe [Yu.A. Aleksandrovsky, N.G. Neznanov, Editors, 2-nd edition, revised and enlarged]. Moscow: GEHOTAR-Media, 2018. (In Russ.)

19. Ukaz Prezidenta Rossijskoj Federacii N 690 ot 9 iyunya 2010 goda «Ob utverzhdenii Strategii gosudarstvennoj antinarkoticheskoj politiki Rossijskoj Federacii do 2020 goda» [Decree No. 690 of the President of the Russian Federation of June 9, 2010 «On the Approval of the Strategy of the State Anti-Drug Policy of the Russian Federation until 2020»]. (In Russ.)

20. Federal'noe rukovodstvo po ispol'zovaniyu lekarstvennyh sredstv (formulyarnaya sistema). Vypusk XVII [Federal guidelines for the use of medicines (formular system). Issue XVII.] Ìoscow: Vidox, 2016: 313-322. (In Russ.)

21. Federal'nyj zakon ot 08.01.1998 N 3-FZ (red. ot 29.12.2017) «O narkoticheskih sredstvah i psihotropnyh veshchestvah» [Federal Law of 08.01.1998 N 3-FZ (Edited on December 29, 2017) «On narcotic drugs and psychotropic substances.»] (In Russ.)

22. Federal'nyj zakon ot 21.11.2011 N 323-FZ (red. ot 03.07.2016) «Ob osnovah ohrany zdorov'ya grazhdan v Rossijskoj Federacii» [Federal Law No. 323-FZ of November 21, 2011 (as amended on 03.07.2016) «On the fundamentals of protecting the health of citizens in the Russian Federation.»] (In Russ.)

23. Federal'nyj zakon ot 7 dekabrya 2011 g. ¹ 420-FZ «O vnesenii izmenenij v Ugolovnyj kodeks Rossijskoj Federacii i otdel'nye zakonodatel'nye akty Rossijskoj Federacii» [Federal Law of December 7, 2011 No. 420-FZ «On Amendments to the Criminal Code of the Russian Federation and Certain Legislative Acts of the Russian Federation.»] (In Russ.)

24. Brewer C., Krupitsky E. Antagonists for the treatment of opioid dependence. In: Interventions for addiction: comprehensive addictive behaviors and disorders. San Diego: Academic press. 2013. P. 427-438.

25. Center for Substance Abuse Treatment. Detoxification and Substance Abuse Treatment. Treatment Improvement Protocol (TIP) Series 45. DHHS Publication No. (SMA) 06-4131. Rockville, MD: Substance Abuse and Mental Health Services Administration, 2006.

26. Drug Misuse. Opioid detoxification. National Clinical Practice Guideline Number 52. National Collaborating Centre for Mental Health commissioned by the National Institute for Health & Clinical Excellence. British Psychological Society and the Royal College of Psychiatrists, 2008.

27. Kämmerer N., Lemenager T., Grosshans M., Kiefer F., Hermann D. Pregabalin for the reduction of opiate withdrawal symptoms. Psychiatr Prax. 2012; 39 (7): 351-2.

28. Kleber H.D. Detoxification from narcotics. In: Lowinson, J.H., Ruitz P. eds.: Substance abuse, clinical problems and perspectives. Baltimore, Williams & Wilkins, 1981: 317-338.

29. Krupitsky E., Woody G.E., Zvartau E., O'Brien C.P. Addiction treatment in Russia. Lancet 2010; 376 (9747): 1145.

30. Krupitsky E., Zvartau E., Woody G. Use of different drug formulations of opioid antagonist (naltrexone) to treat opioid dependence in Russia. In Textbook of addiction treatment: international perspectives. el-Guebaly N., Carrà G., Galanter M. (Eds). Springer-Verlag, 2015:521-530. doi 10.1007/978-88-470-5322-9.

31. Krupitsky E.M., Zvartau E.E., Masalov D.V., Tsoi M.V., Burakov A.M., Didenko T.Y., Romanova T.N., Ivanova E.B., Egorova V.Y., Bespalov A.Y., Verbitskaya E.V., Martynikhin A.V., Neznanov N.G., Grinenko A.Y., Woody G. A double-blind, placebo-controlled clinical trial of naltrexone for heroin addiction and HIV risk reduction in Russia. NIDA satellite sessions with the XIV international AIDS conference. Barcelona, Spain, July 7-11. 2002: 86-89.

32. Krupitsky E.M., Zvartau E.E., Masalov D.V., Tsoi M.V., Burakov A.M., Egorova V.Y., Didenko T.Y., Romanova T.N., Ivanova E.B., Bespalov A.Y., Verbitskaya E.V., Neznanov N.G., Grinenko A.Y., O’Brien C.P., Woody G.E. Naltrexone for heroin dependence treatment in St. Petersburg, Russia. Journal of substance abuse treatment 2004; 26 (4): 285-294.

33. Krupitsky E.M., Zwartau E.E., Masalov D.V., Tsoy M.V., Burakov A.M., Egorova V.Y., Didenko T.Y., Romanova T.N., Ivanova E.B., Bespalov A.Y., Verbitskaya E.V., Neznanov N.G., Grinenko A.Y., O’Brien C.P., Woody G.E. Naltrexone with or without fluoxetine for preventing relapse to heroin addiction in St. Petersburg, Russia. Journal of substance abuse treatment 2006; 31 (4): 319-328.

34. Lingford-Hughes A.R., Welch S., Peters L., Nutt D.J. et al. BAP updated guidelines: evidence-based guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP. J. Psychopharmacol. 2012; 26 (7): 899-952. doi: 10.1177/0269881112444324.

35. Martínez-Raga J., Sabater A., Perez-Galvez B., Castellano M., Cervera G. Add-on gabapentin in the treatment of opiate withdrawal. Prog. Neuropsychopharmacol Biol. Psychiatry 2004; 28 (3): 599-601.

36. Martinotti G. Pregabalin in clinical psychiatry and addiction: pros and cons. Expert Opin Investig Drugs 2012; 21 (9): 1243-1245.

37. McGlone L., Hamilton R., McCulloch D.L., MacKinnon J.R., Bradnam M., Mactier H. Visual outcome in infants born to drug-misusing mothers prescribed methadone in pregnancy. British Journal of Ophthalmology 2014; 98 (2): 238-45.

38. Minozzi S., Amato L., Vecchi S. (2011) Oral naltrexone maintenance treatment for opioid dependence. Cochrane Database Syst Rev 2011; (4). doi: 10.1002/14651858.CD001333.pub4.

39. Naltrexone for the management of opioid dependence: NICE technology appraisal guidance 115. London: National Institute for Health and Clinical Excellence, 2007.

40. Pinkofsky H.B., Hahn A.M., Campbell F.A., Rueda J., Daley D.C., Douaihy A.B. Reduction of opioid-withdrawal symptoms with quetiapine. Clin Psychiatry. 2005; 66 (10):1285-8.

41. Riordan C.E., Kleber H.D. Rapid opiate detoxification with clonidine and naloxone. Lancet 1980; 1 (8177): 1079-80.

42. Salehi M., Kheirabadi G.R., Maracy M.R., Ranjkesh M. Importance of gabapentin dose in treatment of opioid withdrawal. Clin Psychopharmacol. 2011; 31(5): 593-6. doi: 10.1097/JCP.0b013e31822bb378.

43. WHO Guidelines for the psychosocially assisted pharmacological treatment of opioid dependence. World Health Organization, 2009.