Authors
Chepranova Zh. Yu.
Doctor of Medicine, Professor, Head, Chair for Nervous Diseases and Restorative Medicine1
Yatsenko Ye. A.
Assistant Professor, Chair for Nervous Diseases and Restorative Medicine1
Lisikh Ye. A.
Assistant, Chair for Nervous Diseases and Restorative Medicine1
Kapustina Z. A.
Student of the 6th year, Medical institute, Faculty of General Medicine1
1 - Federal State Autonomous Educational Institution of Higher Education «Belgorod National Research University», Belgorod, Russia
Corresponding Author
Kapustina Zlata Alexandrovna, e-mail: yourfuturedoctor24@gmail.com
Conflict of interest
None declared.
Funding
The study had no sponsorship.
Abstract
Ischemic stroke is the most common severe pathology among all the forms of cerebrovascular diseases. Nowadays the problem of pathogenetic therapy is relevant because of the high lethality and persistent disability of patients who have suffered from stroke. The aim of the study is to analyze the activation of internal genetically determined compensatory adaptive protective mechanisms which have been developed during the evolution progress and to use it as a pathogenic method of treating for the ischemic insult. The article provides analysis of national and foreign scientific reports from 2000 to 2017, determining the experimental and clinical studies of ischemic preconditioning. The possibility of its application in clinical practice is considered, the data on the effectiveness of endogenous protective mechanisms and neuroprotection are given, the conclusion about the relevance and scientific and practical significance of studies devoted to the phenomenon of preconditioning is made.
Key words
ischemic preconditioning, ischemic insult, ischemic tolerance, neuroprotection
DOI
References
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