The study of the metabolic profile of cannabimimetic MDMB-2201 in urine using gas chromatography with mass spectrometric detection

Kataev S. S.
PhD, Head, Forensic Chemistry Department¹

Dvorskaya O. N.
PhD, Assistant Professor, Chair for Toxicological Chemistry²

Gofenberg M. A.
Head, Chemical and Toxicological Laboratory³⁴; Senior Lecturer⁵

Dunilin A. V.
Head, Chemical and Toxicological Laboratory⁶

1Perm Regional Bureau of Forensic-Medical Expertise, Perm, Russia
2Perm State Pharmaceutical Academy, Perm, Russia
3Yekaterinburg Regional Narcological Clinic, Yekaterinburg, Russia
4Sverdlovsk Regional Clinical Psychiatric Hospital, Yekaterinburg, Russia
5Ural State Medical University, Yekaterinburg, Russia.
6Kurgan Regional Narcoligical Clinic, Kurgan, Russia.

Dvorskaya Oksana, e-mail: dvoksnik@gmail.com

The study had no sponsorship.

The authors declare no conflict of interest.

The first cases of identifying consumers of cannabimimetics MDMB-2201 during urine testing for narcotic substances in the Russian Federation were registered in March-April 2019 in the cities of Tyumen, Yekaterinburg, and Kurgan., 15 main metabolites and markers of the cannabimimetic MDMB-2201 were identified in the urine of consumers of smoking mixtures using solid-phase extraction and gas chromatography with mass spectrometric detection. Mass spectra of electronic ionization of the identified metabolites of MDMB-2201 were obtained, the results of calculations of several physicochemical characteristics and the degree of conjugation of metabolites to establish the facts of taking the cannabimimetic MDMB-2201 in the analysis of obtained biologic objects are presented.

MDMB-2201, cannabimimetics, metabolites, urine, solid-phase extraction (SPE), gas chromatography – mass spectrometry (GC-MS)

10.29234/2308-9113-2019-7-3-104-120

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