Authors
Litvinov A. S.
MD, PhD, Leading Scientific Specialist1; Deputy General Director for Medical Issues2
Savin A. V.
Leading Specialist3, Nephrologist4
Kuhtina A. A.
Resident Physician, Chair for Outpatient Therapy5
1 - «Metaco LLP», London, United Kingdom
2 - LLC «Agidel Medical center», Ufa, Russia
3 - YugEkoService LLC, Rostov-on-Don, Russia
4 - Limited Partnership «Harmony Medical Clinic», Rostov-on-Don, Russia
5 - Moscow State Medical and Dental University Named After A. I. Evdokimov, Moscow, Russia
Corresponding Author
Litvinov S. Alexander; e-mail: dirge@yandex.ru
Conflict of interest
None declared.
Funding
The study had no sponsorship.
Abstract
In this article we discussed the mechanisms of infection with SARS-CoV-2, intercellular interactions and ways of infection transmission. We considered the epidemiology of COVID-19 and covered in detail the prospects of involving other organs and systems other than the respiratory system in maintaining the viral load. Problems of immune protection of the human body during infection with SARS-CoV-2 have been identified. Clinical parallels with progenitor viruses, namely SARS-CoV-1 and MERS-CoV, have been drawn. Risk factors for SARS-CoV-2 infection were identified, which allow predicting the course and probable outcomes of COVID-19.
Key words
SARS-CoV-2, COVID-19, angiotensin converting enzyme 2, angiotensin 1-7, transmembrane protease, serine 2, target cell, type 2 alveocyte
DOI
References
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