Biological Activity of New 1-Benzoyl-Subctituted 6-(Methylthio)-4-Chloro-1h-Pyrazolo[3,4-D]Pyrimidines

Ofitserova E. S.
Postgraduate, Chair for Organic Chemistry¹

Alekseeva L. N.
PhD (Pharmacy)¹

Shklyarenko A. A.
Postgraduate, Chair for Organic Chemistry¹

Yakovlev I. P.
Doctor of Chemistry, Professor¹

1St. Petersburg State University of Chemistry and Pharmacy, Ministry of Health of the Russian Federation, St. Petersburg, Russia

Ekaterina S. Ofitserova; e-mail: OfizerovaES@mail.ru

None declared.

The study had no sponsorship.

The article presents results of the study of the biological activity of newly synthesized 1-benzoyl-substituted-6- (methylthio) -4-chloro-1H-pyrazolo [3,4-d] pyrimidines. The acute toxicity of 2-aryl-6- (methylthio) -4-chloro-2H-pyrazolo [3,4-d] pyrimidines was determined experimentally on non-linear white male mice with a total weight of 16-20 g. A generation model was used to experimentally evaluate the analgesic activity acetic «writhing» in mice. It was experimentally confirmed that the synthesized new 2-aryl-6- (methylthio) -4-chloro-2H-pyrazolo [3,4-d] pyrimidines are non-toxic and have pronounced analgesic activity.

1-Benzoyl-Subctituted 6-(Methylthio)-4-Chloro-1h-Pyrazolo[3,4-D]Pyrimidines, biologic activity, PASS program, acute toxicity, analgesic activity

10.29234/2308-9113-2020-8-3-76-84

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