Authors
Shinko T. G.
Postgraduate Student, Chair for Pharmaceutical Chemistry1
Terentyeva S. V.
Doctor of Pharmacy, Professor, Chair for Pharmaceutical Chemistry1
Yagunov S. Ye.
Senior Lecturer, Chair for Chemistry2
Prosenko O. I.
PhD in Chemistry, Associate Professor, Chair for Chemistry2
Kandalintseva N. V.
PhD in Chemistry, Professor, Chair for Chemistry; Head, Institute of Natural and Socio-Economic sciences2
Ivanovskaya E. A.
Doctor of Pharmacy, Professor, Head, Chair for Pharmaceutical Chemistry1
1 - Novosibirsk State Medical University, Novosibirsk, Russia
2 - Novosibirsk State Pedagogical University, Novosibirsk, Russia
Corresponding Author
Shinko Tatiana; e-mail:shinko.tatiana@yandex.ru
Conflict of interest
None declared.
Funding
The study had no sponsorship.
Abstract
The prevention and the therapy of such diseases as atherosclerosis, hepatitis, and cancer is nowadays one of the most significant medical problems. Dodecyl(3,5-dimethyl-4-hydroxybenzyl)sulfide was synthesized at the chair for chemistry of Novosibirsk State Pedagogical University. This substance is a new promising phenolic antioxidant, which can be used in the complex therapy of abovementioned diseases. The aim of this study was to develop methods for quantification of dodecyl(3,5-dimethyl-4-hydroxybenzyl)sulfide for standardization and bioanalytical studies. The mercurimetric titration, HPLC-UV and voltammetry were used. The methods validation was performed according to general pharmacopoeial monograph OFS.1.1.0012.15 «Analytical methods validation» and OFS.1.1.0013.15 «Statistical processing of chemical experiment results» of the Russian State Pharmacopoeia XIV. All the results meet the acceptance criteria in parameters specificity, linearity, precision and accuracy. The mercurimetric titration of dodecyl(3,5-dimethyl-4-hydroxybenzyl)sulfide is recommended for including in chapter «Assay» of the original monograph project for substance. The HPLC-UV method may be useful for the determination of the object of study in dosage forms. The voltammetric method is promising for bioanalytical researches.
Key words
dodecyl(3,5-dimethyl-4-hydroxybenzyl)sulfide, quantitative determination, standardization, titration, HPLC, voltammetry
DOI
References
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