Modeling drugs’ dosage adjustments in responsible self-treatment of chronic diseases

Gelman V. Ya.
Doctor of Technical Sciences, Professor, Chair for Medical Informatics and Physics¹

1 - North-West State Medical University named after I.I. Mechnikov, St. Petersburg, Russian Federation

Gelman Viktor; e-mail: Viktor.Gelman@szgmu.ru.

None declared.

The study had no sponsorship.

Responsible self-treatment in chronic diseases involves adjustment of the drug’s dose depending on monitoring data. The aim of the study was to simulate the adjustment of dosage of drugs in responsible self-treatment of chronic diseases and to find methods for calculating current dosages. The methodological basis of the work were methods of mathematical modeling and control theory. The case of discrete control with the introduction of a feedback loop is considered. A method for calculating the dosage of a drug is proposed, taking into account the individual sensitivity of the patient and external uncontrolled influences. The use of the proposed method will improve the quality of control and, accordingly, the effectiveness of the treatment process.

dose adjustment, drug, responsible self-treatment, chronic disease, modeling

10.29234/2308-9113-2023-11-1-14-24

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