Main Pathologic Effects of Exposure to Highly Dispersed E-Cigarette Aerosol on Lung Cells and Respiratory Epithelium: Literature Review

Sinyakin I. A.
6th-year Student, Faculty of Medicine¹

Shestakova M. A.
6th-year Student, Faculty of Medicine¹

Beshlyaga O. Y.
6th-year Student, Faculty of Medicine¹

Batalova T. A.
Doctor of Biology, Head, Chair for Physiology and Pathophysiology¹

1 - Amur State Medical Academy of the Ministry of Health of Russia, Blagoveshchensk, Russian Federation

Sinyakin Ivan Alekseevich; e-mail: sinyakinscience2000@vk.com

The authors declare no conflict of interest.

The study had no sponsorship.

Objective. To determine the pathologic role of highly dispersed e-cigarette aerosol on lung cells, respiratory epithelium, and the immune system. Results. A systematic analysis of scientific literature in the databases: PubMed, ResearchGate, Medscape, and Cochrane Library was performed. The search was conducted using the following keywords: e-cigarette, vape, juul, lung, airway, respiratory, respiratory, cough, methacholine, nasal, alveoli, immune, bronchial, tracheal, bronchoalveolar, nicotine, propylene glycol, vegetable glycerol, macrophages, epithelium, spirometry and SPF1. Based on the literature review, the following conclusion was reached: studies show measurable adverse biological effects on the bronchopulmonary apparatus in humans, animals, and in vitro. The pathologic effects of e-cigarettes have similarities to the effects of tobacco smoke on the pulmonary parenchyma. Conclusion. Analysis of the literature makes it possible to come to the conclusion that current knowledge of these pathologic effects is insufficient to determine whether exposure to e-cigarettes is less pathologic for the respiratory system than exposure to combustible tobacco products.

electronic cigarettes, vapes, high-disperse aerosol, lung cancer, pneumonitis

10.29234/2308-9113-2024-12-1-72-87

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