AboutContactsEditorial StaffEditorial CouncilArchiveFor AuthorsFor Reviewers

Modern Possibilities of Correction of Sexual Dysfunction in Women with Neurological Diseases. A Review.

Journal «MEDICINA» ¹ 1, 2024, pp.88-108 (Reviews)

Authors

Mirkhamidova N. A.
Basic doctoral student, Chair for Rehabilitation, Traditional Medicine and Physical Education1

Usmankhodjaeva A. A.
MD, PhD, Assistant Professor, Head, Chair for Rehabilitation, Traditional Medicine and Physical Education1

1 - Tashkent Medical Academy, Tashkent, Uzbekistan

Corresponding Author

Nargiza Mirkhamidova Abdurahmon qizi; e-mail: nargiza.mirxamidova@tma.uz

Conflict of interest

None declared.

Funding

The study had no sponsorship.

Abstract

The purpose of the study is to analyze research publications on sexual dysfunction, modern possibilities of diagnosis and treatment of this condition in women with neurological diseases. Material and methods. The search for literary sources was carried out in the electronic databases PubMed Central, MEDLINE, Science Direct, Cochrane Library in the period from 2000 to 2023. Conclusions. Sexual dysfunction (SD) is a fairly common problem affecting on average about 60% of female patients suffering from various neurological diseases. The presence of SD significantly impairs physical, psychological and social parameters of women's health. The number of studies dealing with the problem of SD is quite limited. It should be noted that the development of differentiated comprehensive rehabilitation programs for patients with SD is a qualitatively new approach and is potentially effective in the management of SD. However, there is currently insufficient data for the application of complex methods of recovery and treatment of SD, which implies further study of the effectiveness of various methods of correction of SD in clinical trials.

Key words

sexual dysfunction, quality of life, neurological diseases, physical rehabilitation, young and middle-aged women, multiple sclerosis, spinal cord injury, Parkinson disease, stroke, traumatic brain injury

DOI

References

1. Mirkhamidova N., Usmankhodjaeva A., & Artikkhodjaeva D. Ñlinical features of sexual dysfunctions in women with neurological diseases. Norwegian Journal of Development of the International Science 2022; 98: 33-35, doi: 10.5281/zenodo.7437284

2. Anderson K.D. Targeting recovery: priorities of the spinal cord-injured population. J Neurotrauma 2004; 21(10):1371-1383, doi: 10.1089/neu.2004.21.1371

3. Almalki D.M., Kotb M.A., Albarrak A.M. Discussing sexuality with patients with neurological diseases: A survey among neurologists working in Saudi Arabia. Front Neurol. 2023; 14: 1083864, doi: 10.3389/fneur.2023.1083864

4. Rees P.M, Fowler C.J., Maas C.P. Sexual function in men and women with neurological disorders. Lancet 2007; 369(9560): 512-525, doi: 10.1016/s0140-6736(07)60238-4

5. Chandler B.J., Brown S. Sex and relationship dysfunction in neurological disability. J Neurol Neurosurg Psychiat. 1998; 65(6):877-880, doi: 10.1136/jnnp.65.6.877

6. Sandel M.E., Williams K.S., Dellapietra L., Derogatis L.R. Sexual functioning following traumatic brain injury. Brain Injury 1996; 10(10): 719-728, doi: 10.1080/026990596123981

7. Giaquinto S., Buzzelli S., Nolfe G. Evaluation of sexual changes after stroke. J Clin Psychiatry 2003; 64(3): 302-307, doi: 10.4088/jcp.v64n0312

8. Courtois F., Gerard M., Charvier K., D.B. Vodusek, G. Amarenco. Assessment of sexual function in women with neurological disorders: A review. Ann. Phys. Rehabil. Med 2018; 61(4): 235-244, doi: 10.1016/j.rehab.2017.04.004

9. Santos-García D., de la Fuente-Fernández R. Impact of non-motor symptoms on health-related and perceived quality of life in Parkinson’s disease. J Neurol Sci. 2013; 332(1-2):136-140, doi: 10.1016/j.jns.2013.07.005

10. Lundberg P.O. Sexual dysfunction in female patients with multiple sclerosis. Int Rehabil Med. 1981; 3(1): 32-34, doi: 10.3109/03790798109167112

11. Nazari F., Shaygannejad V., Sichani M.M., Mansourian M., Hajhashemi V. Sexual dysfunction in women with multiple sclerosis: prevalence and impact on quality of life. BMC Urol. 2020; 20(1): 15, doi: 10.1186/s12894-020-0581-2

12. Contreras D., Lillo, S., Vera-Villarroel P. Subjective Sexual Well-Being in Chilean Adults: evaluation of a Predictive Model. J Sex Marital Ther 2016; 42(4): 338-352, doi: 10.1080/0092623x.2015.1053018

13. Fisher W.A., Donahue K.L., Long J.S., Heiman J.R., Rosen R.C., Sand M.S. Individual and Partner Correlates of Sexual Satisfaction and Relationship Happiness in Midlife Couples: Dyadic Analysis of the International Survey of Relationships. Arch Sex Behav 2015; 44(6): 1609-1620, doi: 10.1007/s10508-014-0426-8

14. Nortvedt M.W., Riise T., Myhr K.M., Landtblom A.M., Bakke A., Nyland H.I. Reduced quality of life among multiple sclerosis patients with sexual disturbance and bladder dysfunction. Mult Scler 2001; 7(4): 231-235, doi: 10.1177/135245850100700404

15. Demirkiran M., Sarica Y., Uguz S., Yerdelen D., Aslan K. Multiple sclerosis patients with and without sexual dysfunction: are there any differences? Mult Scler 2006; 12(2): 209-214, doi: 10.1191/135248506ms1253oa

16. Tepavcevic D.K., Kostic J., Basuroski I.D., Stojsavljevic N., Pekmezovic T., Drulovic J. The impact of sexual dysfunction on the quality of life measured by MSQoL-54 in patients with multiple sclerosis. Mult Scler 2008; 14(8): 1131-1136, doi: 10.1177/1352458508093619

17. Amato M.P. A decline in cognitive function should lead to a change in disease-modifying therapy – Commentary. Mult Scler 2018; 24(13): 1685-1686, doi: 10.1177/1352458518787721

18. Brauers L., Rameckers E., Severijns D., Feys P., Smeets R., Klingels K. Measuring Motor Fatigability in the Upper Limbs in Individuals with Neurologic Disorders: A Systematic Review. Arch Phys Med Rehabil. 2020; 101(5): 907-916, doi: 10.1016/j.apmr.2019.11.015

19. Motl R.W., Sandroff B.M., Kwakkel G., Dalgas U., Feinstein A., Heesen C., Thompson A.J. Exercise in patients with multiple sclerosis. Lancet Neurol 2017; 16(10): 848-856, doi: 10.1016/s1474-4422(17)30281-8

20. Sadeghi Bahmani D., Motl R.W. Rate, burden, and treatment of sexual dysfunction in multiple sclerosis: The case for exercise training as a new treatment approach. Mult Scler Relat Disord. 2021; 51: 102878, doi: 10.1016/j.msard.2021.102878

21. Drulovic J., Kisic-Tepavcevic D., Pekmezovic T. Epidemiology, diagnosis and management of sexual dysfunction in multiple sclerosis. Acta Neurol Belg. 2020; 120(4): 791-797, doi: 10.1007/s13760-020-01323-4

22. Alba Pal´e L., Le´on Caballero J., Sams´o Buxareu B., Salgado Serrano P., P´erez Sol`a V. Systematic review of depression in patients with multiple sclerosis and its relationship to interferonβ treatment. Mult Scler Relat Disord, 2017; 17: 138-143, doi: 10.1016/j.msard.2017.07.008

23. Borello-France D., Leng W., O’Leary M., et al. Bladder and sexual function among women with multiple sclerosis. Multiple Sclerosis Journal 2004; 10(4): 455-461, doi: https://doi.org/10.1191/1352458504ms1060oa 10.1191/1352458504ms1060oa

24. Gava G., Visconti M., Salvi F., Bartolomei I., Seracchioli R., Meriggiola M.C. Prevalence and Psychopathological Determinants of Sexual Dysfunction and Related Distress in Women with and Without Multiple Sclerosis. J Sex Med. 2019; 16(6): 833-842, doi: 10.1016/j.jsxm.2019.03.011

25. Mohammadi K., Rahnama P., Rafei Z., Ebrahimi-Aveh S.M., Montazeri A. Factors associated with intimacy and sexuality among young women with multiple sclerosis. Reprod Health. 2020; 17(1): 110, doi: 10.1186/s12978-020-00960-5

26. Zhao Z., Zhang Y., Du Q., Chen H., Shi Z., Wang J., Zhou H. Differences in physical, mental, and social functions between males and females in multiple sclerosis: a multicenter cross-sectional study in China. Mult Scler Relat Disord. 2020; 48: 102693, doi: 10.1016/j.msard.2020.102693

27. Pottgen J., Rose A., van de Vis W., Engelbrecht J., Pirard M., Lau S., Kopke S. Sexual dysfunctions in MS in relation to neuropsychiatric aspects and its psychological treatment: a scoping review. PLoS ONE 2018; 13(2): e0193381, doi: 10.1371/journal.pone.0193381

28. Kisic Tepavcevic D., Pekmezovic T., Dujmovic Basuroski I., Mesaros S., Drulovic J. Bladder dysfunction in multiple sclerosis: a 6-year follow-up study. Acta Neurol Belg. 2017; 117(1): 83-90, doi: 10.1007/s13760-016-0741-z

29. Orasanu B., Frasure H., Wyman A., Mahajan S.T. Sexual dysfunction in patients with multiple sclerosis. Mult Scler Relat Disord. 2013; 2(2): 117-123, doi: 10.1016/j.msard.2013.02.003

30. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, 5th edition. American Psychiatric Association, Arlington VA, 2013, doi: 10.1176/appi.books.9780890425596

31. IsHak W.W., Tobia G, DSM-5 Changes in Diagnostic Criteria of Sexual Dysfunctions. Reprod Sys Sexual Disorders 2013; 2(2): 1000122, doi: 10.4172/2161-038X.1000122

32. Van Lankveld JDM. Veranderde classificatie van seksuele disfuncties [Changes in classification of sexual dysfunction: from DSM-IV-TR to DSM-5]. Ned Tijdschr Geneeskd. 2018; 162: D2750.

33. Chen L., Shi G.R., Huang D.D., Li Y., Ma C.C., Shi M., Shi G.J. Male sexual dysfunction: a review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention. Biomed Pharmacother. 2019; 112: 108585, doi: 10.1016/j.biopha.2019.01.046

34. Chen C.H., Lin Y.C., Chiu L.H., Chu Y.H., Ruan F.F., Liu W.M., Wang P.H. Female sexual dysfunction: definition, classification, and debates. Taiwan J Obstet Gynecol. 2013; 52(1): 3-7, doi: 10.1016/j.tjog.2013.01.002

35. Kleinplatz P.J. History of the Treatment of Female Sexual Dysfunction(s). Annu Rev Clin Psychol. 2018; 14: 29-54, doi: 10.1146/annurev-clinpsy-050817-084802

36. Krysko K.M., Graves J.S., Dobson R., Altintas A., Amato M.P., Bernard J., et al. Sex effects across the lifespan in women with multiple sclerosis. Ther Adv Neurol Disord, 2020; 13: 1756286420936166, doi: 10.1177/1756286420936166

37. Dawson M.L., Shah N.M., Rinko R.C., Veselis C., Whitmore K.E. The evaluation and management of female sexual dysfunction. J Fam Pract. 2017; 66(12): 722-728.

38. Rosen R., Brown C., Heiman J., Leiblum S., Meston C., Shabsigh R., D’Agostino R. The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther. 2000; 26(2): 191-208, doi: 10.1080/009262300278597

39. Derogatis L.R., Rosen R., Leiblum S., Burnett A., Heiman J. The Female Sexual Distress Scale (FSDS): initial validation of a standardized scale for assessment of sexually related personal distress in women. J Sex Marital Ther 2002; 28(4): 317-330, doi: 10.1080/00926230290001448

40. Rogalski M.J., Kellogg-Spadt S., Hoffmann A.R., Fariello J.Y., Whitmore K.E. Retrospective chart review of vaginal diazepam suppository use in high-tone pelvic floor dysfunction. Int Urogynecol J 2010; 21(7): 895-899, doi: 10.1007/s00192-009-1075-7

41. Mykletun A., Dahl A.A., O’Leary M.P., Fossa S.D. Assessment of male sexual function by the Brief Sexual Function Inventory. BJU Int. 2006; 97(2): 316-323, doi: 10.1111/j.1464-410x.2005.05904.x

42. Rosen R.C., Riley A., Wagner G., Osterloh I.H., Kirkpatrick J., Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49(6): 822-830, doi: 10.1016/s0090-4295(97)00238-0

43. Wallin M.T., Culpepper W.J., Campbell J.D., Nelson L.M., Langer-Gould A., Marrie R. A., LaRocca N.G. The prevalence of MS in the United States: a population-based estimate using health claims data. Neurology 2019; 92(10): e1029–e1040, doi: 10.1212/wnl.0000000000007035

44. Redelman M.J. Sexual difficulties for persons with multiple sclerosis in New South Wales, Australia. International Journal of Rehabilitation Research 2009; 32(4): 337-347, doi: 10.1097/mrr.0b013e3283298166

45. Bronner G., Elran E., Golomb J., Korczyn A.D. Female sexuality in multiple sclerosis: the multidimensional nature of the problem and the intervention. Acta Neurol Scand 2010; 121(5): 289-301, doi: 10.1111/j.1600-0404.2009.01314.x

46. Cordeau D., Courtois F. Sexual disorders in women with MS: assessment and management. Ann Phys Rehabil Med. 2014; 57(5): 337-347, doi: 10.1016/j.rehab.2014.05.008

47. Rogalski M.J., Kellogg-Spadt S., Hoffmann A.R., Fariello J.Y., Whitmore K.E. Retrospective chart review of vaginal diazepam suppository use in high-tone pelvic floor dysfunction. Int Urogynecol J. 2010; 21(7): 895-899, doi: 10.1007/s00192-009-1075-7

48. Aftab A., Chen C., McBride J. Flibanserin and its discontents. Arch Womens Ment Health 2017; 20(2): 243-247, doi: 10.1007/s00737-016-0693-6

49. Archer D.F., Simon J.A., Portman D.J., Goldstein S.R., Goldstein I., Ospemifene for the treatment of menopausal vaginal dryness, a symptom of the genitourinary syndrome of menopause. Expert Review of Endocrinology & Metabolism 2019; 14(5): 301-314, doi: 10.1080/17446651.2019.1657008

50. Farnia V., Hojatitabar S., Shakeri J., Rezaei M., Yazdchi K., Bajoghli H., Brand S. Adjuvant Rosa Damascena has a Small Effect on SSRI-induced Sexual Dysfunction in Female Patients Suffering from MDD. Pharmacopsychiatry 2015; 48(4-5): 156-163, doi: 10.1055/s-0035-1554712

51. Farnia V., Alikhani M., Ebrahimi A., Golshani S., Sadeghi Bahmani D., Brand S., Ginseng treatment improves the sexual side effects of methadone maintenance treatment. Psychiatry Res 2019; 276: 142-150, doi: 10.1016/j.psychres.2019.05.004

52. Weinberger J.M., Houman J., Caron A.T., Anger J. Female Sexual Dysfunction: a Systematic Review of Outcomes Across Various Treatment Modalities. Sex Med Rev 2019; 7(2): 223-250, doi: 10.1016/j.sxmr.2017.12.004

53. Lombardi G., Macchiarella A., Del Popolo G. Efficacy and safety of tadalafil for erectile dysfunction in patients with multiple sclerosis. J Sex Med 2010; 7(6): 2192-2200, doi: 10.1111/j.1743-6109.2010.01797.x

54. Xiao Y., Wang J., Luo H. Sildenafil citrate for erectile dysfunction in patients with multiple sclerosis. Cochrane Database Syst Rev. 2012; (4): Cd009427, doi: 10.1002/14651858.cd009427.pub2

55. Calabr`o R.S., De Luca R., Conti-Nibali V., Reitano S., Leo A., Bramanti P. Sexual dysfunction in male patients with multiple sclerosis: a need for counseling! Int J Neurosci, 2014; 124(8): 547-557, doi: 10.3109/00207454.2013.865183

56. Jain A., Iqbal O.A. Alprostadil In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2023; PMID: 31194374

57. Blackmore D.E., Hart S.L., Albiani J.J., Mohr D.C. Improvements in partner support predict sexual satisfaction among individuals with multiple sclerosis. Rehabil Psychol. 2011; 56(2): 117-122, doi: 10.1037/a0023362

58. Buss D.M. Evolutionary Psychology. The new Science of the Mind, 6th edition. Routledge, New York, 2019. ISBN: 13: 978-1138088610

59. Audrey S.B., Marion R., Béatrice M., Stéphane V., Katelyne H. Sexual Dysfunction in Women with Multiple Sclerosis: Expectations Regarding Treatment and Information, and Utility of the SEA-MS-F Questionnaire. Sex Med. 2022; 10(3): 100502, doi: 10.1016/j.esxm.2022.100502

60. Sabanagic-Hajric S., Memic-Serdarevic A., Sulejmanpasic G., Mehmedika-Suljic E. Influence of Sociodemographic and Clinical Characteristics on Sexual Function Domains of Health Related Quality of Life in Multiple Sclerosis Patients. Mater Sociomed. 2022; 34(3): 188-192, doi: 10.5455/msm.2022.34.188-192

61. Lorenz T.A., Meston C.M. Acute exercise improves physical sexual arousal in women taking antidepressants. Ann Behav Med 2012; 43(3): 352-361, doi: 10.1007/s12160-011-9338-1

62. Lorenz T.A., Meston C.M. Exercise improves sexual function in women taking antidepressants: results from a randomized crossover trial. Depress Anxiety 2014; 31(3): 188-195, doi: 10.1002/da.22208

63. Lopes I.P., Ribeiro V.B., Reis R.M., Silva R.C., Dutra de Souza H.C., Kogure G.S., Silva Lara L.A.D. Comparison of the Effect of Intermittent and Continuous Aerobic Physical Training on Sexual Function of Women with Polycystic Ovary Syndrome: Randomized Controlled Trial. J Sex Med 2018; 15(11): 1609-1619, doi: 10.1016/j.jsxm.2018.09.002