On the issue of specific manifestations of risk factors of the cardiorenal continuum in the endothelial cell

Lazutkina A. Yu.
MD, PhD, Leading inspector-physician, Department of Organization of Medical Care¹; Junior Researcher²

1Far Eastern Directorate of Healthcare – a structural subdivision of the Central Directorate of Healthcare – a branch of Russian Railways, Khabarovsk, Russian Federation
2Research Laboratory of Biomechanics and Determination of Human Capabilities, Far Eastern State Academy of Physical Culture of the Ministry of Sports of the Russian Federation, Khabarovsk, Russian Federation

Lazutkina Anna; e-mail: Lazutkina_AU59@mail.ru

The study had no sponsorship.

None declared.

Introduction. Reducing the impact of key risk factors (RFs) for circulatory diseases has the potential to increase life expectancy, but unique target organ tissue-specific indicators of their impact remain unclear. The aim of the study: To find out distinctive manifestations of the influence of RFs at the cellular level in the chain of events of the cardiorenal continuum (CRC) using the example of a group of initially healthy 7.959 male using the methods of applied statistics. Materials and methods. The data of the CRC created in the process of studying cardiovascular outcomes in workers of locomotive crews of the Trans-Baikal Railway established over 6 years of observation were used to clarify the specific feature of the implementation of each predictor in the endothelial cell (EC) of the CRC. Results. The formation of endothelial dysfunction (ED) under the influence of the same predictors has significant differences in different areas of the vascular bed. The differences lie in the dynamics of ED progression at different stages the formation of a specific final outcome of the CRC. The first stage of ED does not change, which may be due to the production of the same ED markers by the endothelium under the influence of a specific RF. Conclusion. To neutralize the effect of pathogenic risk factors before irreversible changes in the EC and prevent CRC events, targeted studies are needed to clarify the quantitative and qualitative values ​​of morpho-biochemical markers of ED.

chronic kidney disease, interaction, cardiorenal continuum, sudden cardiac death, risk factors, endothelial dysfunction, predictors

10.29234/2308-9113-2026-14-1-1-18

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