Use of autologous cellular technology (ACT) in closure of macular holes

Chuprov A. D.¹
Professor, doctor of medical science, director;
ORCID: 0000-0001-7011-4220

Firsov A. S.¹
Head of the Ophthalmology Department;
ORCID: 0000-0001-5523-7927; SPIN: 9278-3867

Trubnikov V. A.¹
Candidate of Medical Sciences, Deputy Director for Organizational and Methodological Work;
ORCID: 0000-0002-9451-8622; SPIN: 2002-1951

Kazakova T. V.¹
Candidate of Biological Sciences, Head of the Research and Education Department;
ORCID: 0000-0003-3717-4533; SPIN: 1283-1267

1Orenburg branch of The S. Fyodorov Eye Microsurgery Federal State Institution, Orenburg, Russia

Firsov A.S., e-mail: nauka@ofmntk.ru

The study had no sponsorship.

None declared.

10.04.2025

12.05.2026

The article presents the experience of the Orenburg branch of The S. Fyodorov Eye Microsurgery Federal State Institution in the use of the technology of closing macular holes using ACT. The obtained results indicate a significant improvement in the anatomical and functional parameters of the retina. Successful regeneration of the macula and statistically significant increase in visual acuity in the operated patients indicate the prospects of this method in ophthalmosurgical practice.

macular hole, retina, subtotal vitrectomy, autologous cellular technology (ACT), patient's blood plasma

10.29234/2308-9113-2026-14-3-140-149

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