Diuretic Activity of the Juices of The Alchemilla Vulgaris Fresh Herb

Cheremnykh E. V.
Assistant, Chair for Pharmacognosy¹

Boyarshinov V. D.
senior lecturer, Chair for Pharmacology¹

Zorina E. V.
PhD (Pharmaceutical Sciences), Assistant Professor, Chair for Pharmacognosy¹

Belonogova V. D.
Doctor of Pharmaceutical Sciences, Head, Chair for Pharmacognosy¹

1 - Perm State Pharmaceutical Academy, Perm, Russian Federation

Cheremnykh E. V.; e-mail: chl1978@yandex.ru

None declared.

The study had no sponsorship.

The search for new herbal diuretics with minimal risks of undesirable side effects is promising. In traditional medicine, the herb of the Alchemilla is used to treat diseases of the urinary system. The purpose of the study is to investigate the diuretic activity of the herb juice of Alchemilla. The subjects of the study were native juice of Alchemilla vulgaris fresh herb and juice of Alchemilla vulgaris fresh herb subjected to cold stimulation for 7 and 14 days. The diuretic activity of the juices was determined in white male outbred rats. The concentration of sodium and potassium electrolytes in the urine was determined by X-ray fluorescent method. Differences in the manifestation of diuretic activity of juices were identified. Diuretic activity was detected in the Alchemilla vulgaris fresh herb juice, subjected to cold stimulation for 7 days. Exposure of raw material to cold and its duration affects the manifestation of diuretic activity of juices.

diuretic activity, Alchemilla vulgaris, lady's mantle, juice, cold stimulation

10.29234/2308-9113-2024-12-2-64-70

1. Bavrina A.P. Sovremennye pravila primeneniya parametricheskih i neparametricheskih kriteriev v statisticheskom analize mediko-biologicheskih dannyh. [Modern rules for the application of parametric and non-parametric criteria in the statistical analysis of biomedical data.] Medicinskij al'manah [Medical almanac] 2021; (1): 64-73. (In Russ.)

2. Berkhin E.B. Metody izucheniya vliyaniya novyh himicheskih soedinenij na funkciyu pochek. [Methods for studying the effect of new chemical compounds on kidney function.] Himiko-farmacevticheskij zhurnal [Chemical-pharmaceutical journal] 1977; T.11; (5); 3-11. (In Russ.)

3. Bryukhanov V.M., Zverev Ya.F., Lampatov V.V., Zharikov A.Yu. Metodicheskie podhody k izucheniyu funkcii pochek v eksperimente na zhivotnyh. [Methodological approaches to the study of kidney function in animal experiments.] Nefrologiya [Nephrology] 2009; 13(3): 52-62. (In Russ.)

4. Zaprometov M.N. Fenol'nye soedineniya: Rasprostranenie, metabolizm i funkcii v rasteniyah. [Phenolic compounds: Distribution, metabolism and functions in plants.] Moscow: Nauka, 1993. 271 p. (In Russ.)

5. Kurkin V.A., Pravdivtseva O.E., Zaitseva E.N., Dubishchev A.V., Tsibina A.S., Kurkina A.V., Pervushkin S.V., Zhdanova A.V. Terpenoidy i fenol'nye soedineniya kak biologicheski aktivnye soedineniya lekarstvennyh rastenij, obladayushchih diureticheskim dejstviem. [Terpenoids and phenolic compounds as biologically active compounds of medicinal plants with diuretic effect.] Farmaciya i farmakologiya [Pharmacy and pharmacology] 2023; 11(6): 446-460, doi: 10.19163/2307-9266-2023-11-6-446-460 (In Russ.)

6. Lobanova I.E., Vysochina G.I., Mazurkova N.A., Kukushkina T.A., Filippova E.I. Vidy roda Alchemilla l. (Rosaceae): himicheskij sostav, biologicheskaya aktivnost', ispol'zovanie v medicine (obzor). [Species of the genus Alchemilla l. (Rosaceae): chemical composition, biological activity, medicinal use (review).] Himiya rastitel'nogo syr'ya [Chemistry of plant materials] 2019; (1): 5-22. (In Russ.)

7. Rumyantseva E.I. Hronicheskaya bolezn' pochek kak global'naya problema dlya obshchestvennogo zdorov'ya: dinamika zabolevaemosti i smertnosti. [Chronic kidney disease as a global public health problem: dynamics of morbidity and mortality.] Problemy standartizacii v zdravoohranenii [Problems of standardization in healthcare] 2021; (1-2): 41-49, doi: 10.26347/1607-2502202101-02041-049 (In Russ.)

8. Tovchiga O.V., Shtyrgol S.Yu. Vliyanie lekarstvennyh rastenij na vydelitel'nuyu funkciyu pochek. [The effect of medicinal plants on the excretory function of the kidneys.] Eksperimental'naya i klinicheskaya farmakologiya [Experimental and clinical pharmacology] 2009; 72(3): 50-59. (In Russ.)

9. Khalmatov Kh.Kh. Rasteniya Uzbekistana s diureticheskim dejstviem. [Plants of Uzbekistan with a diuretic effect.] Tashkent: Medicina, 1979. (In Russ.)

10. Cheremnykh E.V., Zorina E.V., Belonogova V.D. Vliyanie biostimulyacii travy manzhetki obyknovennoj svezhej na himicheskij sostav i antioksidantnuyu aktivnost' soka. [The effect of biostimulation of fresh Alchemilla vulgaris herb on the chemical composition and antioxidant activity of juice.] Vestnik Smolenskoj gosudarstvennoj medicinskoj akademii [Bulletin of the Smolensk State Medical Academy] 2023; 22(4): 229-235, doi: 10.37903/vsgma.2023.4.31 EDN: YJSBTZ (In Russ.)

11. Shulga M.A., Pogorelova E.I., Panina O.A. Rasprostranennost' osnovnyh faktorov riska serdechno-sosudistyh zabolevanij sredi razlichnyh grupp naseleniya. [Prevalence of the main risk factors for cardiovascular diseases among various population groups.] Kompleksnye problemy serdechno-sosudistyh zabolevanij [Complex problems of cardiovascular diseases] 2021; 10(S2): 183.